Support for these products includes validated manufacturing methods, secure long-term medium supply, safe and easy handling, and regulatory support files (RSF) to assist process validation and submissions to regulatory authorities. These features in combination with the ability to run Capto S ImpAct at high flow rates and bed heights increase productivity and flexibility in process design. Capto S ImpAct is available in a broad range of scalable formats supporting high-throughput process development as well as in bulk for the full manufacturing-scale process.Ĭapto S ImpAct is part of the BioProcess™ medium family comprising chromatography media widely used by biopharmaceutical manufacturers. Capto S Cation Exchanger for post-Protein A Purification of Monoclonal. The polymeric ligand design, in combination with the attributes of the base matrix, gives a cation exchanger with high binding capacity. effects of the factors are sufficiently defined by model equations, those. By combining the rigidity of Capto media with an optimised bead size, Capto S ImpAct exhibits both excellent pressure/flow properties and resolution, even at high sample load. ![]() Capto S ImpAct is based on the high-flow Capto base matrix. The medium is designed for polishing of monoclonal antibodies (MAbs) and a wide range of other biomolecules. Running conditions: AxiChrom 1000 for Capto S, Chromaflow 1000 for Q Sepharose Fast Flow, 20 cm packed bed, with water at 20C. Additional chromatography resins can be available in the ReadyToProcess column format upon request. The full offering is listed in Product sheet 29161435. ![]() Pressure/flow curve for Capto S compared to Q Sepharose Fast Flow. are MabSelect PrismA, MabSelect SuRe, MabSelect, Capto S ImpAct, Capto ImpRes, Capto, Sepharose 6 Fast Flow, and Sepharose High Performance resins. Our Capto™ S ImpAct.Ĭapto S ImpAct chromatography medium (resin) is a strong cation exchanger. capacities of Capto S, Capto Q, and Capto DEAE at different residence times are shown in Figure 3. Posted on OctoMAb polishing on your mind.
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